This is just another one for the hopper.
The system and setting is Over the Edge, with a minor setting tweak; the D’Aubainnes are not quite as powerful in international terms as they are in vanilla OtE, so they need to worry more about maintaining a delicate balance between the USSR, China, and the United States.
The campaign framework: there’s a United States consulate located in The Edge. The D’Aubainnes are not currently allowing the United States to have an embassy in Freedom City, although Russia does have one. All PCs work for the consulate, whether they’re American citizens or local employees. Preferably mostly the former, I think. Obvious archetypes: the consul himself, who could be a bright young kid looking to make his name at State, or a cynical veteran, or someone being punished for a screwup elsewhere. The CIA rep under cover as an agricultural attache. The press attache/PR spokesman/cultural activity organizer. (“Hey, kids, wanna learn baseball?”) The US citizen who sought and was granted asylum in the consulate but can’t return to the States for complex legal reasons. The local working as a secretary.
PCs deal with the interesting and diverse problems that US citizens bring to them; I’d have a lot of room to drive stories. Also plenty of room for the PCs to drive their own stories. I’d expect plenty of espionage stuff. Mystic shit depends on the degree of player desire. Some horror, of course.
Influences are Charlie Wilson’s War, The Quiet American, etc.