I’ve been kicking around a lucha libre Scion game in my mind, along with a couple of other ideas (Southern Gothic comes to mind), but I think the winner is 17th century pirates who happen to be children of gods.
We’d wanna finish up our Catholic saint pantheon, for obvious reasons. Voodoo fits well, Aztecs fit just fine. Greek gods? Sure. Norse gods? Very well, given the Norse tradition of rampaging around on boats. Egyptian and Japanese are a little tougher, but I have ideas.
And it’s not at all difficult to make Caribbean piracy mythic and grand.