(Not Fringeworthy, that’s different.)
Use Nemesis, which is fairly simple and free. A couple of nomenclature changes — Madness Meters are Stability Meters, and most difficulties are fairly low. Things are weird but not alien weird. The Unnatural track is the Fringe track. Trump dice are likewise Fringe dice.
There is no supernatural, but there is fringe science, obviously. Those versed in fringe science might go above 5d in a given stat. I wouldn’t be surprised if Nina turned out to have 6d in Body, and Dr. Bishop has 6d Mind. Perhaps more.
Regular combat still exists. Right now the show looks more procedural than actiony, which means firearms should be deadly, which I think they are in Nemesis. However, the interesting combat scenes are scientific. This works more or less like regular combat.
1. Declare your character’s action. The show’s set up with one main scientist, which works fine — everyone else does supporting actions, which feed back into the scientist’s work, giving him bonus dice.
2. Roll the appropriate dice pool. Narrate accordingly. Sometimes it’s going to be science skill vs. science skill (can we figure out how to undo this dimensional transposition before it explodes in downtown Boston?), and sometimes it’d be science skill vs. something else. I think the whole tank scene in the pilot was vs. tactics, for example.
3. Damage is to be contemplated. Could be physical. Could be time ebbing away. Possibly losing a fight results in Stability Meter checks. Mostly I think I like time passing; a lot of this stuff is going to be mad science on the clock, since it’s a procedural show. So it’s… when you run out of wound boxes, you’re out of time or the experiment failed.
You don’t have weapons. You have centrifuges, which get statted up the same way.