Justin suggested the Titanic as a mashup subject, and that seemed like a pretty good idea to me. I’m not going to use the movie as source material, since I’ve never seen it, but don’t let that stop you.
For this, I return (as I often do) to Trinity. While there are obvious parallels with the destruction of the Esperanza, one of the seminal events in the Trinity timeline, that’s not the direction I want to go. So where?
The Moon. I’d parallel the Titanic tragedy with an accident on the lunar soil; probably a dome blowout, in classic SF style. I’d use the blowout as the initial linkage between characters. (Might be a good chance to use the one-shot opener technique, come to think of it.) There’s a movie like this, and I can’t for the life of me remember what it was.
Anyhow, the goal is to do a heavily character-driven game in which PCs come to terms, or not, with the after-effects of tragedy. Part of my goal would be a conscious effort to reprioritize the effects of death in a roleplaying game, in a manner somewhat less satiric than Power Kill or Violence. I’d use the usual Trinity plot as a backdrop, but it wouldn’t be the focus of the game.